Loss of heterozygosity exploited for collateral lethality

Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be involved in the somatic loss of wild-type ...

Loss of heterozygosity (LOH) is a type of genetic abnormality in diploid organisms in which one copy of an entire gene and its surrounding chromosomal region ... In cancer · Knudson two-hit hypothesis of... · Copy-neutral LOH · Detecti

Loss of heterozygosity (LOH) is a mitotic recombination event that converts heterozygous loci to homozygous loci. This mutation event is widespread in ...

Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be involved in the somatic loss of wild-type ...

When the loss of heterozygosity involves the normal allele, it creates a cell that is more likely to show malignant growth if the altered gene is a tumor ...

LOH (short for “loss of heterozygosity”) refers to a type of mutation that results in the loss of one copy of a segment of DNA (typically containing a gene ...

LOH occurs when a cancer cell that is originally heterozygous at a locus loses one of its two alleles at that locus, either by simple deletion ...

Loss of heterozygosity (LOH) commonly refers to the loss by mutation or deletion of one of two heterogeneous alleles of a tumor suppressor gene in cancer cells.

As a common genetic event during cancer development, loss of heterozygosity (LOH) results in the loss of one allele of a gene, ...